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Cholesterol-Lowering Drugs Might Deteriorate Muscles, Nervous System

According to a new study, statin-stimulated drugs that are recommended to patients having high levels of cholesterol might weaken the patient’s nervous system and muscles. As per to the research, which has been unveiled in the Cell Metabolism journal, statin lowers the configuration of brown adipose tissue which aids in the conversion of sugar to fat into heat. People having brown adipose tissue are good at managing their body temperature in the winter season and are less prone to suffer from diabetes or excess weight.

A team of investigators focused the fact that how bad white fat cells—which create the layer of fat beneath our skin—become superior brown fat cells. After conducting cell culture experiments, the scientist found that the biochemical passageway is responsible for creating cholesterol to play an important role in this transformation. They also determined that the crucial molecule regulating the conversion is the metabolite geranylgeranyl pyrophosphate. Scientists also investigated positron emission tomography screening of 8,500 patients. This allows them to find whether the individual is having brown adipose tissue or not. After inspecting the scans it was concluded that 6% of those who not take the drugs had brown adipose tissue, but this type of tissue was present in only 1 % of those who were taking statins. Christian Wolfrum—a researcher at ETH, Zurich—stated, “We also have to mull over that statins are extremely important as a way to avert cardiovascular disease. They hoard millions of lives around the globe and they are recommended for a very good reason.”

Recently, the ETH, Zurich was also in news for printing the stiffest potential material by 3D technology. In a joint effort amid researchers at MIT and ETH, Zurich, a material was 3D printed with a rigidity that comes particularly close to the hypothetical maximum boundary of stiffness to weight ratio achievable, according to the physics laws.